The role of multidimensional poverty in antibiotic misuse: a mixed-methods study of self-medication and non-adherence in Kenya, Tanzania, and Uganda

Authors: Dominique L Green PhD a, Katherine Keenan PhD a, Kathryn J Fredricks PhD a, Sarah I Huque PhD a, Martha F Mushi PhD d, Catherine Kansiime PhD h, Benon Asiimwe PhD f, John Kiiru PhD i, Prof Stephen E Mshana MD d, Prof Stella Neema PhD g, Joseph R Mwanga PhD e, Mike Kesby PhD a, Prof Andy G Lynch PhD b c, Hannah Worthington PhD b, Emmanuel Olamijuwon PhD a, Mary Abed Al Ahad MSc a, Annette Aduda MA i, John Mwaniki Njeru PhD i, Prof Blandina T Mmbaga PhD j k, Joel Bazira PhD l…Madeleine Clarkson

Poverty is a proposed driver of antimicrobial resistance, influencing inappropriate antibiotic use in low-income and middle-income countries (LMICs). However, at subnational levels, studies investigating multidimensional poverty and antibiotic misuse are sparse, and the results are inconsistent. We aimed to investigate the relationship between multidimensional poverty and antibiotic use in patient populations in Kenya, Tanzania, and Uganda.

Published at:  2022-12-13

Impact of N-Acetyl Cysteine (NAC) on Tuberculosis (TB)Patients—A Systematic Review

Daniel Adon Mapamba 1, 2, * , Elingarami Sauli 2, Lucy Mrema 1, Julieth Lalashowi 1, David Magombola 1,Joram Buza 2, Willyhelmina Olomi 1, Robert S. Wallis 3and Nyanda Elias Ntinginya 1, *

Sustained TB infection overproduces reactive oxygen species (ROS) as a host defensemechanism. Research shows ROS is destructive to lung tissue. Glutathione (GSH) neutralizes ROS,although it is consumed. NAC is a precursor of GSH synthesis, and administering an appropriatedose of NAC to patients with respiratory conditions may enhance lung recovery and replenishGSH. The present review searched for articles reporting on the effects of NAC in TB treatment from1960 to 31 May 2022. The PICO search strategy was used in Google Scholar, PubMed, SciFinder, andWiley online library databases..........

Published at:  2022-11-21

Indicators of optimal diabetes care and burden of diabetes complications in Africa: a systematic review and meta-analysis

Authors: Davis Kibirige1, Nyasatu Chamba2,3, Irene Andia-Biraro4,5, Kajiru Kilonzo2,3, Sweetness Naftal Laizer3, Isaac Sekitoleko6, Andrew Peter Kyazze4, Sandra Ninsiima7, Phillip Ssekamatte7, Felix Bongomin8, Lucy Elauteri Mrema9, Willyhelmina Olomi10, Theodora D Mbunda9, Nyanda Elias Ntinginya9, Issa Sabi11, Katrina Sharples12, Philip Hill12, Lindsey te Brake13, Josephine VandeMaat14, Reinout vanCrevel15,16, Julia Alison Critchley17

Objective Contemporary data on the attainment of optimal diabetes treatment goals and the burden of diabetes complications in adult populations with type 2 diabetes in Africa are lacking. We aimed to document the current status of attainment of three key indicators of optimal diabetes care and the prevalence of five diabetes complications in adult African populations with type 2 diabetes.

Published at:  2022-11-08

Systematic assessment of clinical and bacteriological markers for tuberculosis reveals discordance and inaccuracy of symptom-based diagnosis for treatment response monitoring

Authors: Bariki Mtafya1,2*, Issa Sabi1, Joseph John1, Emanuel Sichone1, Wilyhelmina Olomi1, Stephen H. Gillespie2, Nyanda E. Ntinginya1† and Wilber Sabiiti2†

Clinical symptoms are the benchmark of tuberculosis (TB) diagnosis and monitoring of treatment response but are not clear how they relate to TB bacteriology, particularly the novel tuberculosis-molecular bacterial load assay (TB-MBLA).

Published at:  2022-10-28

Prevalence, clusters, and burden of complex tuberculosis multimorbidity in low- and middle-income countries: a systematic review and meta-analysis

Alexander Jarde, Ruimin Ma, Olamide O. Todowede, Abdul Latif, Aashifa Yaqoob, Saima Afaq, Tarana Ferdous, Ewan M Tomeny, Laura Rosu, Lucy Elauteri Mrema, Shagoofa Rakhshanda, Sheraz Fazid, Farah Naz Rahman, Uzochukwu Egere, Asma Elsony, Helen Elsey, Kamran Siddiqi, Brendon Stubbs, View ORCID ProfileNajma Siddiqi

The co-occurrence of tuberculosis (TB) and multiple chronic communicable and non-communicable diseases is a growing concern in low- and middle-income countries (LMICs). Understanding this ‘complex TB multimorbidity’ (cTBMM) can contribute to improved patient care. We aimed to synthesise the prevalence of clusters of cTBMM and their impact on patient outcomes....

Published at:  2022-09-23

Phylogenetic lineages of tuberculosis isolates and their association with patient demographics in Tanzania

uthors: Beatrice Kemilembe Mutayoba, Michael Hoelscher, Norbert Heinrich, Moses L. Joloba, Eligius Lyamuya, Andrew Martin Kilale, Nyagosya Segere Range, Bernard James Ngowi, Nyanda Elias Ntinginya, Saidi Mwinjuma Mfaume, Amani Wilfred, Basra Doulla, Johnson Lyimo, Riziki Kisonga, Amri Kingalu, Jupiter Marina Kabahita, Ocung Guido, Joel Kabugo, Isa Adam, Moses Luutu, Maria Magdalene Namaganda, Joanitah Namutebi, George William Kasule, Hasfah Nakato, Henry Byabajungu, Pius Lutaaya, Kenneth Musisi, Denis Oola, Gerald Mboowa & Michel Pletschette

Mycobacterium tuberculosis presents several lineages each with distinct characteristics of evolutionary status, transmissibility, drug resistance, host interaction, latency, and vaccine efficacy. Whole genome sequencing (WGS) has emerged as a new diagnostic tool to reliably inform the occurrence of phylogenetic lineages of Mycobacterium tuberculosis and examine their relationship with patient demographic characteristics and multidrug-resistance development.

Published at:  2022-08-05

HIV testing and linkage to care—A case of a mobile diagnostic and counseling service in Mbeya, Tanzania; A quantitative study

Amani Kway ,Issa Sabi ,Willyhelmina Olomi ,Ruby Doryn Mcharo ,Erica Sanga ,Wiston William ,Ombeni Chimbe ,Nyanda Elias Ntinginya ,Lucas Maganga

HIV-care programmes are faced with significant challenges in getting newly diagnosed People Living with Human Immunodeficiency Virus (PLHIV) linked to care despite massive investment in HIV prevention, treatment and care. This study assessed the performance of mobile HIV Testing and Counseling service (mHTC) in provision of HIV-testing and linkage to care of newly diagnosed PLHIV from Key and Vulnerable Populations (KVPs)......

Published at:  2022-08-04

Rifapentine and isoniazid for prevention of tuberculosis in people with diabetes (PROTID): protocol for a randomised controlled trial

Authors: Nyanda Elias Ntinginya, Lindsey te Brake, Issa Sabi, Nyasatu Chamba, Kajiru Kilonzo, Sweetness Laizer, Irene Andia-Biraro, Davis Kibirige, Andrew Peter Kyazze, Sandra Ninsiima, Julia A. Critchley, Renee Romeo, Josephine van de Maat, Willyhelmina Olomi, Lucy Mrema, David Magombola, Issakwisa Habakkuk Mwayula, Katrina Sharples, Philip C. Hill & Reinout van Crevel On behalf of the PROTID Consortium

Diabetes mellitus (DM) increases the risk of tuberculosis (TB) and will hamper global TB control due to the dramatic rise in type 2 DM in TB-endemic settings. In this trial, we will examine the efficacy and safety of TB preventive therapy against the development of TB disease in people with DM who have latent TB infection (LTBI), with a 12-week course of rifapentine and isoniazid (3HP)

Published at:  2022-06-10

Health-related quality of life and psychological distress among adults in Tanzania: a cross-sectional study

Authors: Olena Ivanova, Tembeka Sineke, Rebekka Wenzel, Elimina Siyame, Julieth Lalashowi, Abhishek Bakuli, Fidelina Cumbe Zekoll, Michael Hoelscher, Andrea Rachow, Denise Evans, Issa Sabi & Nyanda Elias Ntinginya

Little data is available on health-related quality of life (HRQoL) and mental health of the general population in Tanzania. We aimed to describe HRQoL and level of psychological distress among adults in Mbeya and Songwe Regions of Tanzania.

Published at:  2022-05-24

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