Bedaquiline, moxifloxacin, pretomanid, and pyrazinamide during the first 8 weeks of treatment of patients with drug-susceptible or drug-resistant pulmonary tuberculosis: a multicentre, open-label, partially randomised, phase 2b trial

Authors: Conor D Tweed MD a, Rodney Dawson MD b c, Divan A Burger PhD d, Almari Conradie MPharm e, Angela M Crook PhD a, Carl M Mendel MD f, Francesca Conradie MBBCh g, Andreas H Diacon MD h i, Nyanda E Ntinginya PhD j, Daniel E Everitt MD f, Frederick Haraka MD k, Mengchun Li MD f, Christo H van Niekerk MD e, Alphonse Okwera PhD l, Mohammed S Rassool MBChB m, Klaus Reither PhD k n, Modulakgotla A Sebe MBChB o, Suzanne Staples MPhil p, Ebrahim Variava MD q, Melvin Spigelman MD f

New anti-tuberculosis regimens that are shorter, simpler, and less toxic than those that are currently available are needed as part of the global effort to address the tuberculosis epidemic. We aimed to investigate the bactericidal activity and safety profile of combinations of bedaquiline, pretomanid, moxifloxacin, and pyrazinamide in the first 8 weeks of treatment of pulmonary tuberculosis. ........

Published at:  2019-11-12

Wuchereria bancrofti infection is linked to systemic activation of CD4 and CD8 T cells

Inge Kroidl ,Mkunde Chachage,Jonathan Mnkai,Anthony Nsojo,Myrna Berninghoff,Jaco J. Verweij,Lucas Maganga,Nyanda E. Ntinginya,Leonard Maboko,Petra Clowes,Michael Hoelscher,Elmar Saathoff ,Christof Geldmacher

Susceptibility to HIV has been linked to systemic CD4+ T cell activation in cohorts of seronegative individuals with high HIV-exposure risk. We recently described an increased risk of HIV transmission in individuals infected with Wuchereria bancrofti, the causative agent for lymphatic filariasis, in a prospective cohort study. However, the reason for this phenomenon needs further investigation.

Published at:  2019-08-19

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