Early Depletion of Mycobacterium tuberculosis-Specific T Helper 1 Cell Responses after HIV-1 Infection

Christof Geldmacher, Alexandra Schuetz, Njabulo Ngwenyama, Joseph P. Casazza, Erica Sanga, Elmar Saathoff, Catharina Boehme, Steffen Geis, Leonard Maboko, Mahavir Singh, Fred Minja, Andreas Meyerhans, Richard A. Koup, Michael Hoelscher

The acid-fast bacillus Mycobacterium tuberculosis is often the first manifestation of acquired immunodeficiency syndrome in patients infected with human immunodeficiency virus (HIV). This study was conducted to better understand the mechanism underlying M. tuberculosis-specific pathogenicity early after onset of HIV infection

Published at:  2008-12-01

Laboratory reference values for healthy adults from southern Tanzania

Elmar Saathoff, Philine Schneider, Vera Kleinfeldt, Steffen Geis, Dennis Haule, Leonard Maboko, Eleuter Samky, Mark de Souza, Merlin Robb, Michael Hoelscher

Clinical laboratory reference ranges are an important tool for identifying abnormal laboratory results and for ultimately guiding patient management decisions. Because measured laboratory parameters are influenced not only by individual factors such as age, sex, lifestyle, etc. but also by population and ecological factors such as ethnic background, climate and altitude, they vary not only between individuals but also between populations

Published at:  2008-04-16

Peptide Impurities in Commercial Synthetic Peptides and Their Implications for Vaccine Trial Assessment

Authors: Jeffrey R. Currier, Lynee M. Galley, Holger Wenschuh, Vivian Morafo, Silvia Ratto-Kim, Clive M. Gray, Leonard Maboko, Michael Hoelscher, Mary A. Marovich, Josephine H. Cox

The advent of T-cell assay methodologies that are amenable to high throughput coupled with the availability of large libraries of overlapping peptides have revolutionized the fields of vaccine efficacy testing and cellular immune response assessment. Since T-cell assay performance is critically dependent upon the quality and specificity of the stimulating peptides, assurance of high-quality and reliable input peptides is an important aspect of assay validation. Herein, we demonstrate that individual peptides from large human immunodeficiency virus.........

Published at:  2008-02-01

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