Linkage into care among newly diagnosed HIV-positive individuals tested through outreach and facility-based HIV testing models in Mbeya, Tanzania: a prospective mixed-method cohort study

Erica Samson Sanga1,2, Wondwossen Lerebo2,3, Adiel K Mushi4, Petra Clowes1,5, Willyhelmina Olomi1, Leonard Maboko1, Christina Zarowsky2,6

Linkage to care is the bridge between HIV testing and HIV treatment, care and support. In Tanzania, mobile testing aims to address historically low testing rates. Linkage to care was reported at 14% in 2009 and 28% in 2014. The study compares linkage to care of HIV-positive individuals tested at mobile/outreach versus public health facility-based services within the first 6 months of HIV diagnosis

Published at:  2017-04-12

Assessment of the novel T-cell activation marker–tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study

Authors: Damien Portevin PhD a b, Felicien Moukambi MSc c d, Petra Clowes MD c d, Asli Bauer PhD c d, Mkunde Chachage PhD c, Nyanda E Ntinginya MD c, Elirehema Mfinanga MD f, Khadija Said MD f, Frederick Haraka MD f, Andrea Rachow MD d e, Elmar Saathoff PhD d e, Maximilian Mpina MSc f, Levan Jugheli PhD a b f, Fred Lwilla PhD f, Prof Ben J Marais FCPaed g, Prof Michael Hoelscher FRCP d e, Prof Claudia Daubenberger DVM a b, Dr Klaus Reither MD a b f †, Dr Christof Geldmacher PhD d e

The diagnosis of paediatric tuberculosis is complicated by non-specific symptoms, difficult specimen collection, and the paucibacillary nature of the disease. We assessed the accuracy of a novel immunodiagnostic T-cell activation marker–tuberculosis (TAM-TB) assay in a proof-of-concept study to identify children with active tuberculosis.

Published at:  2014-10-15

Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection

Milan Raska, Lydie Czernekova, Zina Moldoveanu, Katerina Zachova, Matt C Elliott, Zdenek Novak, Stacy Hall, Michael Hoelscher, Leonard Maboko, Rhubell Brown, Phillip D Smith, Jiri Mestecky & Jan Novak

HIV-1 entry into host cells is mediated by interactions between the virus envelope glycoprotein (gp120/gp41) and host-cell receptors. N-glycans represent approximately 50% of the molecular mass of gp120 and serve as potential antigenic determinants and/or as a shield against immune recognition. We previously reported that N-glycosylation of recombinant gp120 varied, depending on the producer cells, and the glycosylation variability affected gp120 recognition by serum antibodies from persons infected with HIV-1 subtype B. However..........

Published at:  2014-08-01

Seroprevalence of Alphavirus Antibodies in a Cross-Sectional Study in Southwestern Tanzania Suggests Endemic Circulation of Chikungunya

Nina Weller ,Petra Clowes ,Gerhard Dobler,Elmar Saathoff,Inge Kroidl,Nyanda Elias Ntinginya,Leonard Maboko,Thomas Löscher,Michael Hoelscher,Norbert Heinrich

To date, Alphavirus infections and their most prominent member, chikungunya fever, a viral disease which first became apparent in Tanzania in 1953, have been very little investigated in regions without epidemic occurrence. Few data exist on burden of disease and socio-economic and environmental covariates disposing to infection.

Published at:  2014-07-31

Helminth-Associated Systemic Immune Activation and HIV Co-receptor Expression: Response to Albendazole/Praziquantel Treatment

Mkunde Chachage ,Lilli Podola,Petra Clowes,Anthony Nsojo,Asli Bauer,Onesmo Mgaya,Dickens Kowour,Guenter Froeschl,Leonard Maboko,Michael Hoelscher,Elmar Saathoff,Christof Geldmacher

It has been hypothesized that helminth infections increase HIV susceptibility by enhancing systemic immune activation and hence contribute to elevated HIV-1 transmission in sub-Saharan Africa.

Published at:  2014-03-27

Ascaris lumbricoides Infection and Its Relation to Environmental Factors in the Mbeya Region of Tanzania, a Cross-Sectional, Population-Based Study

Steffen Andreas Schüle ,Petra Clowes,Inge Kroidl,Dickens O. Kowuor,Anthony Nsojo,Chacha Mangu,Helene Riess,Christof Geldmacher,Rüdiger Paul Laubender,Seif Mhina,Leonard Maboko,Thomas Löscher,Michael Hoelscher,Elmar Saathoff

With one quarter of the world population infected, the intestinal nematode Ascaris lumbricoides is one of the most common infectious agents, especially in the tropics and sub-tropics. Infection is caused by oral intake of eggs and can cause respiratory and gastrointestinal problems. To identify high risk areas for intervention, it is necessary to understand the effects of climatic, environmental and socio-demographic conditions on A. lumbricoides infection.

Published at:  2014-03-18

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