Reasons for false-positive lipoarabinomannan ELISA results in a Tanzanian population

Inge Kroidl,Petra Clowes,Joshua Mwakyelu,Leonard Maboko,Abubakary Kiangi,Andrea Rachow,

Lipoarabinomannan (LAM), a cell wall component of mycobacteria, can be detected in the urine of tuberculosis (TB) patients. Advantages of this diagnostic include the ease of sample collection and test methods. However, as with most new TB diagnostics, LAM tests have been evaluated in well-controlled laboratory settings and subsequently need assessment under real working conditions. Our experience showed that the diagnosis........

Published at:  2013-11-25

Hookworm Infection and Environmental Factors in Mbeya Region, Tanzania: A Cross-Sectional, Population-Based Study

Helene Riess,Petra Clowes,Inge Kroidl,Dickens O. Kowuor,Anthony Nsojo,Chacha Mangu,Steffen A. Schüle,Ulrich Mansmann,Christof Geldmacher,Seif Mhina,Leonard Maboko,Michael Hoelscher,Elmar Saathoff

Hookworm disease is one of the most common infections and cause of a high disease burden in the tropics and subtropics. Remotely sensed ecological data and model-based geostatistics have been used recently to identify areas in need for hookworm control.

Published at:  2013-09-05

Natural Killer Cell–Mediated Innate Sieve Effect on HIV-1: The Impact of KIR/HLA Polymorphism on HIV-1 Subtype-Specific Acquisition in East Africa

Rebecca N. Koehler, Galit Alter, Sodsai Tovanabutra, Elmar Saathoff, Miguel A. Arroyo, Anne M. Walsh, Eric E. Sanders-Buell, Leonard Maboko, Michael Hoelscher, Merlin L. Robb, Nelson L. Michael, Francine E. McCutchan, Jerome H. Kim, Gustavo H. Kijak

Here we explore the association between killer cell immunoglobulin-like receptor (KIR)/HLA and human immunodeficiency virus type 1 (HIV-1) acquisition with different viral subtypes circulating in East Africa. In the prospective Cohort Development (CODE) cohort (Mbeya, Tanzania), carriers of KIR3DS1 and its putative ligand (HLA-A or HLA-B Bw4-80Ile alleles) showed increased HIV-1 acquisition risk (odds ratio [OR] = 3.46; 95% confidence........

Published at:  2013-08-06

Effect of Genital Herpes on Cervicovaginal HIV Shedding in Women Co-Infected with HIV AND HSV-2 in Tanzania

Jim Todd ,Gabriele Riedner,Leonard Maboko,Michael Hoelscher,Helen A. Weiss,Eligius Lyamuya,David Mabey,Mary Rusizoka,Laurent Belec,Richard Hayes

To compare the presence and quantity of cervicovaginal HIV among HIV seropositive women with clinical herpes, subclinical HSV-2 infection and without HSV-2 infection respectively; to evaluate the association between cervicovaginal HIV and HSV shedding; and identify factors associated with quantity of cervicovaginal HIV.

Published at:  2013-03-13

High Seroprevalence for Typhus Group Rickettsiae, Southwestern Tanzania

Tatjana Dill, 1 Gerhard Dobler, 1 Elmar Saathoff, Petra Clowes, Inge Kroidl, Elias Ntinginya, Harun Machibya, Leonard Maboko, Thomas Löscher, Michael Hoelscher, and Norbert Heinrichcorresponding author

Rickettsioses caused by typhus group rickettsiae have been reported in various African regions. We conducted a cross-sectional survey of 1,227 participants from 9 different sites in the Mbeya region, Tanzania; overall seroprevalence of typhus group rickettsiae was 9.3%. Risk factors identified in multivariable analysis included low vegetation density and highway proximity.

Published at:  2013-02-15

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