Authors: Wilbert Mbuya1*, Issakwisa Mwakyula2, Willyelimina Olomi1, Peter Agrea1, Francesco Nicoli3, Cecilia Ngatunga4, Leodegard Mujwahuzi2, Paul Mwanyika5 and Mkunde Chachage1,6*
People living with HIV, even under therapy, have a high burden of age-related co-morbidities including an increased risk of dyslipidemia (which often predisposes to cardiovascular diseases) and immune-aging. In this study, lipid profiles and antibody responses to measles and pertussis toxin vaccines were compared between ART experienced HIV+ children (n=64) aged 5-10 years, and their age- and sex-matched HIV- controls (n=47). Prevalence of high-density lipoprotein cholesterol (HDL-c) and triglyceride-driven dyslipidemia was higher among treated HIV+ children than in controls (51.6% vs 27.7% respectively, p < 0.019). In a multivariate Poisson regression model adjusted for age, sex and BMI, the association between low HDL-c, hypertriglyceridemia and HIV remained significa................
Published at: 2021-11-09
Authors: Wilbert Mbuya1,2*, Kathrin Held2,3, Ruby D. Mcharo1, Antelmo Haule1, Jacklina Mhizde1, Jonathan Mnkai1, Anifrid Mahenge1, Maria Mwakatima1, Margareth Sembo1, Wolfram Mwalongo1, Peter Agrea1, Michael Hoelscher2,3, Leonard Maboko1,4, Elmar Saathoff2,3, Otto Geisenberger2,3, France Rwegoshora5, Liset Torres5, Richard A. Koup6, Arne Kroidl2,3, Mkunde Chachage1,2,7† and Christof Geldmacher2,3*†
Cervical cancer - caused by persistent High Risk Human Papilloma Virus (HR HPV) infections - is the second most common cancer affecting women globally. HIV infection increases the risk for HPV persistence, associated disease progression and malignant cell transformation. We therefore hypothesized that this risk increase is directly linked to HIV infection associated dysfunction or depletion of HPV-oncoprotein-specific T-cell responses.
Published at: 2021-10-25
Authors: Sacha Horn1†, Dennis Borrero-Wolff2,3†, Manuel Ritter2,3†, Kathrin Arndts2,3, Anna Wiszniewsky2,3, Linda Batsa Debrah4,5,6, Alexander Y. Debrah4,6,7, Jubin Osei-Mensah4,6, Mkunde Chachage1,8,9, Achim Hoerauf2,3,10, Inge Kroidl1,11*‡ and Laura E. Layland2,3,10*‡
CD8+ T cells are crucial for the clearance of viral infections, and current research begins to highlight their importance in parasitic diseases too. In-depth research about characteristics of CD8+ T-cell subsets and exhaustion remains uncertain, especially during filariasis, a chronic helminth infection. Lymphatic filariasis, elicited by Wuchereria bancrofti, remains a serious health problem in endemic areas in Ghana, especially in those suffering from morbidity due to lymphedema (LE). In this observational study, the characteristics and profiles of CD8+ T cells were compared between asymptomatic Wuchereria bancrofti-infected individuals, uninfected endemic normals, and those with LE (grades 2–6). Focusing on exha
Published at: 2021-08-11
Authors: Sayoki G Mfinanga a d, Nicholaus P Mnyambwa a, Daniel T Minja b, Nyanda Elias Ntinginya c, Esther Ngadaya a, Julie Makani e, Abel N Makubi
In a World Report about COVID-19 vaccine use in Tanzania,1 local context was not sufficiently considered to fully understand the country's position on the COVID-19 pandemic and its use of COVID-19 vaccines. We maintain that the late President John Magufuli understood the severity of the COVID-19 pandemic, which merits joint and coordinated global efforts.
Published at: 2021-04-14
Authors: Rehema Moraa Moirongo1 Eva Lorenz1,2,3 Nyanda E. Ntinginya4 Denise Dekker1,2 José Fernandes5,6 Jana Held2,5,6 Maike Lamshöft1,2 Frieder Schaumburg5,7 Chacha Mangu4 Lwitiho Sudi4 Ali Sie8 Aurelia Souares2,9 Norbert Heinrich2,10 Andreas Wieser2,10,11 Benjamin Mordmüller2,5,6,12 Ellis Owusu-Dabo13 Akim Ayola Adegnika5,6,12 Boubacar Coulibaly8 Jürgen May1,2 Daniel Eibach1,2*
Antimicrobial resistance (AMR) thwarts the curative power of drugs and is a present-time global problem. We present data on antimicrobial susceptibility and resistance determinants of bacteria the WHO has highlighted as being key antimicrobial resistance concerns in Africa, to strengthen knowledge of AMR patterns in the region.
Published at: 2020-09-25
Authors: Habakkuk Mwakyula Issakwisa, Gloria Reginald Mbwile, Godlove Fred Mbwanji, David Daniel Nassoro, Nyanda Elias Ntinginya & Anthony Ambikile Nsojo
Despite the significant decline in the prevalence of HIV in Tanzania, the prevalence rates in Mbeya, Iringa, and Njombe regions are higher than the national average and have remained stable for years. The current stable HIV prevalence may be driven by factors such as a high incidence of sexually transmitted infections (STIs) and high-risk behaviours. In sub-Saharan Africa, it has previously been observed that up to 50% of HIV cases were attributed to herpes simplex type 2 (HSV-2) among low-risk populations. Because the proportion of sexually transmitted HSV-1 is rising, it is essential to study the interaction between HSV-1 and HIV infections.
Published at: 2020-08-05
Authors: Conor D Tweed MD a, Rodney Dawson MD b c, Divan A Burger PhD d, Almari Conradie MPharm e, Angela M Crook PhD a, Carl M Mendel MD f, Francesca Conradie MBBCh g, Andreas H Diacon MD h i, Nyanda E Ntinginya PhD j, Daniel E Everitt MD f, Frederick Haraka MD k, Mengchun Li MD f, Christo H van Niekerk MD e, Alphonse Okwera PhD l, Mohammed S Rassool MBChB m, Klaus Reither PhD k n, Modulakgotla A Sebe MBChB o, Suzanne Staples MPhil p, Ebrahim Variava MD q, Melvin Spigelman MD f
New anti-tuberculosis regimens that are shorter, simpler, and less toxic than those that are currently available are needed as part of the global effort to address the tuberculosis epidemic. We aimed to investigate the bactericidal activity and safety profile of combinations of bedaquiline, pretomanid, moxifloxacin, and pyrazinamide in the first 8 weeks of treatment of pulmonary tuberculosis. ........
Published at: 2019-11-12
Inge Kroidl ,Mkunde Chachage,Jonathan Mnkai,Anthony Nsojo,Myrna Berninghoff,Jaco J. Verweij,Lucas Maganga,Nyanda E. Ntinginya,Leonard Maboko,Petra Clowes,Michael Hoelscher,Elmar Saathoff ,Christof Geldmacher
Susceptibility to HIV has been linked to systemic CD4+ T cell activation in cohorts of seronegative individuals with high HIV-exposure risk. We recently described an increased risk of HIV transmission in individuals infected with Wuchereria bancrofti, the causative agent for lymphatic filariasis, in a prospective cohort study. However, the reason for this phenomenon needs further investigation.
Published at: 2019-08-19
Edna O. Viegas ,Arne Kroidl ,Patricia J. Munseri,Marco Missanga,Charlotta Nilsson,Nelson Tembe,Asli Bauer,Agricola Joachim,Sarah Joseph,Philipp Mann,Christof Geldmacher,Sue Fleck,Wolfgang Stöhr,Gabriella Scarlatti,Said Aboud,Muhammad Bakari,Leonard Maboko,Michael Hoelscher,Britta Wahren,Merlin L. Robb,Jonathan Weber,Sheena McCormack,Gunnel Biberfeld,Ilesh V. Jani,Eric Sandström,Eligius Lyamuya,TaMoVac study group
We evaluated the safety and immunogenicity of (i) an intradermal HIV-DNA regimen given with/without intradermal electroporation (EP) as prime and (ii) the impact of boosting with modified vaccinia virus Ankara (HIV-MVA) administered with or without subtype C CN54rgp140 envelope protein adjuvanted with Glucopyranosyl Lipid A (GLA-AF) in volunteers from Tanzania and Mozambique........
Published at: 2018-11-29