Decline in sexually transmitted infection prevalence and HIV incidence in female barworkers attending prevention and care services in Mbeya Region, Tanzania

Riedner, Gabrielea; Hoffmann, Olivera,b; Rusizoka, Maryc; Mmbando, Donanc; Maboko, Leonardd; Grosskurth, Heinera,e; Todd, Jima; Hayes, Richarda; Hoelscher, Michaelb

Female sex workers and their male clients play important roles as core and bridging populations in the epidemiology of sexually transmitted infections (STI) and HIV even in countries with generalized HIV epidemics.

Published at:  2006-02-28

HIV-1 diversity and prevalence differ between urban and rural areas in the Mbeya region of Tanzania

Arroyo, Miguel Aa; Hoelscher, Michaelb; Sateren, Warrena; Samky, Eleuterc; Maboko, Leonardd; Hoffmann, Olivere; Kijak, Gustavof; Robb, Merlinf; Birx, Deborah La; McCutchan, Francine Ef

Inter-subtype recombinant HIV-1, and the co-infections that generate them, are a key feature of the HIV-1 pandemic. Recombination following dual infection with genetically distinct subtypes or strains of HIV-1 is now recognized with increasing frequency in the global epidemic [1–4; Piyasirisilp S, et al. 2005, unpubl. results] HIV-1 risk behaviors and community prevalence often correlate with the frequency of HIV-1 dual infection [Herbinger KH, et al. 2005, unpubl. results]..........

Published at:  2005-09-23

Single-Dose Azithromycin versus Penicillin G Benzathine for the Treatment of Early Syphilis

Gabriele Riedner, M.D., Ph.D., Mary Rusizoka, Dipl.Med., Jim Todd, M.Sc., Leonard Maboko, M.D., Michael Hoelscher, M.D., Donan Mmbando, M.D., Eleuter Samky, M.D., Eligius Lyamuya, Ph.D., David Mabey, M.D., Ph.D., Heiner Grosskurth, M.D., Ph.D., and Richard Hayes, D.Sc.

Pilot studies suggest that a single, 2-g oral dose of azithromycin may be an alternative to a 2.4-MU intramuscular dose of penicillin G benzathine in the prevention and treatment of syphilis. We evaluated the efficacy of treatment with azithromycin in a developing country.

Published at:  2005-09-22

HIV Type 1 Subtypes among Blood Donors in the Mbeya Region of Southwest Tanzania

Miguel A. Arroyo, Michael Hoelscher, Eric Sanders-Buell, Karl-Heinz Herbinger, Eleuter Samky, Leonard Maboko, Oliver Hoffmann, Merlin R. Robb, Deborah L. Birx, and Francine E. McCutchan

HIV-1 is endemic in Tanzania where three different subtypes, A, C, and D, have been identified. Information on HIV-1 genetic diversity is crucial to define requirements for an effective vaccine, in regions where HIV-1 vaccine trials are planned. To define the subtype distribution of HIV-1 in the Mbeya region of southwest Tanzania, peripheral blood mononuclear cells (PBMC) and plasma were obtained from 36 discarded HIV seropositive blood units. Multiregion hybridization assay (MHA) was performed on both PBMC DNA and plasma RNA to determine the subtype distribution. Twenty virtually full-length HIV-1 sequences were amplified from the extracted DNA, sequenced, and phylogenetically analyzed. Subtype distribution......

Published at:  2004-08-25

Thirteen years HIV-1 sentinel surveillance and indicators for behavioural change suggest impact of programme activities in south-west Tanzania

Jordan-Harder, Brigittea; Maboko, Leonardb; Mmbando, Donanb; Riedner, Gabrielec; Nägele, Elisabethd; Harder, Juana; Küchen, Volkere; Kilian, Alberta; Korte, Rolfa; Sonnenburg, Frank vd

To describe the evolution of the HIV-1 epidemic among women attending antenatal clinics in four different geographic areas within two rural regions with differing intervention intensity in south-west Tanzania.

Published at:  2004-01-23

High proportion of unrelated HIV-1 intersubtype recombinants in the Mbeya region of southwest Tanzania

Hoelscher, Michaelab; Kim, Bohyeb; Maboko, Leonardc; Mhalu, Fredd; von Sonnenburg, Franka; Birx, Deborah L.e; McCutchan, Francine E.* and the UNAIDS Network for HIV Isolation and Characterization

In Mbeya, a rural region of southwest Tanzania, HIV-1 subtypes A, C and D have been co-circulating since the early 1990s. Objective To define to what extent the co-existence of subtypes has led to recombinant HIV-1 strains and whether there is evidence for epidemic spread of any circulating recombinant form.

Published at:  2001-08-17

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