Arroyo, Miguel Aa; Hoelscher, Michaelb; Sateren, Warrena; Samky, Eleuterc; Maboko, Leonardd; Hoffmann, Olivere; Kijak, Gustavof; Robb, Merlinf; Birx, Deborah La; McCutchan, Francine Ef
Inter-subtype recombinant HIV-1, and the co-infections that generate them, are a key feature of the HIV-1 pandemic. Recombination following dual infection with genetically distinct subtypes or strains of HIV-1 is now recognized with increasing frequency in the global epidemic [1–4; Piyasirisilp S, et al. 2005, unpubl. results] HIV-1 risk behaviors and community prevalence often correlate with the frequency of HIV-1 dual infection [Herbinger KH, et al. 2005, unpubl. results]..........
Published at: 2005-09-23
Gabriele Riedner, M.D., Ph.D., Mary Rusizoka, Dipl.Med., Jim Todd, M.Sc., Leonard Maboko, M.D., Michael Hoelscher, M.D., Donan Mmbando, M.D., Eleuter Samky, M.D., Eligius Lyamuya, Ph.D., David Mabey, M.D., Ph.D., Heiner Grosskurth, M.D., Ph.D., and Richard Hayes, D.Sc.
Pilot studies suggest that a single, 2-g oral dose of azithromycin may be an alternative to a 2.4-MU intramuscular dose of penicillin G benzathine in the prevention and treatment of syphilis. We evaluated the efficacy of treatment with azithromycin in a developing country.
Published at: 2005-09-22
Miguel A. Arroyo, Michael Hoelscher, Eric Sanders-Buell, Karl-Heinz Herbinger, Eleuter Samky, Leonard Maboko, Oliver Hoffmann, Merlin R. Robb, Deborah L. Birx, and Francine E. McCutchan
HIV-1 is endemic in Tanzania where three different subtypes, A, C, and D, have been identified. Information on HIV-1 genetic diversity is crucial to define requirements for an effective vaccine, in regions where HIV-1 vaccine trials are planned. To define the subtype distribution of HIV-1 in the Mbeya region of southwest Tanzania, peripheral blood mononuclear cells (PBMC) and plasma were obtained from 36 discarded HIV seropositive blood units. Multiregion hybridization assay (MHA) was performed on both PBMC DNA and plasma RNA to determine the subtype distribution. Twenty virtually full-length HIV-1 sequences were amplified from the extracted DNA, sequenced, and phylogenetically analyzed. Subtype distribution......
Published at: 2004-08-25
Jordan-Harder, Brigittea; Maboko, Leonardb; Mmbando, Donanb; Riedner, Gabrielec; Nägele, Elisabethd; Harder, Juana; Küchen, Volkere; Kilian, Alberta; Korte, Rolfa; Sonnenburg, Frank vd
To describe the evolution of the HIV-1 epidemic among women attending antenatal clinics in four different geographic areas within two rural regions with differing intervention intensity in south-west Tanzania.
Published at: 2004-01-23
Hoelscher, Michaelab; Kim, Bohyeb; Maboko, Leonardc; Mhalu, Fredd; von Sonnenburg, Franka; Birx, Deborah L.e; McCutchan, Francine E.* and the UNAIDS Network for HIV Isolation and Characterization
In Mbeya, a rural region of southwest Tanzania, HIV-1 subtypes A, C and D have been co-circulating since the early 1990s. Objective To define to what extent the co-existence of subtypes has led to recombinant HIV-1 strains and whether there is evidence for epidemic spread of any circulating recombinant form.
Published at: 2001-08-17